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Objectives: To assess the effects of oral steroids in patients with multiple nasal polyps. Design: Observational study of 16 polyp patients with a mean age of 20 years (range 20–40 years). The subjects received a single oral dose of steroids at 3 (injected) or 6 month intervals (extended) intervals. The total number of steroids administered during these studies was 467 (150, 200, 280, 560, 650, and 725). Setting: Multivariate analysis of covariance model Patient Population: 16 patients with multiple nasal polyps (n = 16) were randomized to receive 1 dose of steroids or placebo at 3 (injected), 6, or 9 month intervals Intervention: Oral steroids. Main Outcome Measures: Nasal polyps were visualized (number of polyps, size, length, color, surface, etc.) at baseline, 6, and 9 months; clinical assessment of symptoms; and nasal polyps were evaluated at baseline and 6 and 9 months. Results: Of 16 patients, 3 (25%) received a steroids infusion and 2 (10%) were randomized to received placebo. At 6 and 9 months, there were no significant differences from baseline in any of the outcomes. Limitations: The study is population based; patients in the study received multiple injections at 3 or 6-month intervals, all by the same physician. The subjects' demographics did not allow diagnosis of comorbid diseases. The study was poorly powered to detect differences in clinical outcomes between the steroid and placebo groups due to the low sample size. Conclusions: Oral steroids may be effective in reducing multiple nasal polyps, but more research is needed to determine optimal timing and dose. Long-term steroid therapy has not been evaluated in patients with multiple nasal polyps. Similar articles: